Cellular senescence in the intestine can induce cell death, which extends beyond the mere clearance of senescent cells.This phenomenon is prevalent in inflammatory and immune-related diseases, particularly in inflammatory bowel disease (IBD).IBD is characterized by recurrent and chronic intestinal inflammation, with the occurrence and Top Loader de
Summary: Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition.However, some cells eventually override mitotic arrest by mitotic slippage.Here, we show that inactivation of TORC1 kinase elicits mitotic slippage in budding yeast and human cells.Yeast mitotic slippage was
Her Shuang Toh,1 Roxanne Line Faure,2 Liyana Bte Mohd Amin,1 Crystal Yu Fang Hay,1 Saji George1,3 1Centre of Sustainable Nanotechnology, School of Chemical and Life Sciences, Nanyang Polytechnic, Singapore, Singapore; 2DUT Analyses Biologiques et Biochimiques, IUT Génie Biologique, Dijon, France; 3Department of Food Science and Agricultural
Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment.To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component networks on random parameter sets, and assessed the
Bus-bridging evacuation services can significantly enhance metro resilience during operational disruptions.A resilience-based optimization model was proposed to generate a bus bridging and dispatching plan.The objective of the model is to Horse Tail Bags maximize the resilience index of evacuated passengers while meeting pre-established restriction